Tesofensine

Buy Tesofensine Online From Direct Sarms Germany

Tesofensine, originally developed as a treatment for neurodegenerative diseases, has demonstrated promising effects in appetite suppression, enhanced fat metabolism, and substantial weight loss.

NEW REDUCED PRICE

Tesofensine Capsules
Original price was: $242.66.Current price is: $199.57.
Select options
This product has multiple variants. The options may be chosen on the product page

What is Tesofensine?

Tesofensine is a pharmacological compound classified as a new serotonin, norepinephrine, and dopamine reuptake inhibitor. It functions by blocking the reuptake of the three monoaminergic neurotransmitters dopamine, norepinephrine, and serotonin. This action results in elevated levels of these neurotransmitters in the brain, affecting mood, appetite, and energy metabolism.

Initially investigated for the treatment of Parkinson’s and Alzheimer’s diseases due to its indirect enhancement of cholinergic neurotransmission, Germany research shifted focus due to its significant impact on weight loss. TE has demonstrated potential in reducing body weight through decreased appetite and increased energy expenditure. However, it remains under investigation and is designated solely for use in clinical research settings, with no approval for broad human use.

How Does Tesofensine Work?

Tesofensine operates by simultaneously inhibiting the reuptake of three key monoamine neurotransmitters: dopamine, norepinephrine, and serotonin. This mechanism results in higher concentrations of these neurotransmitters in the synaptic cleft, leading to prolonged and enhanced neurotransmitter activity. The increase in dopamine levels contributes to improved mood and reward-related behaviors, which can reduce the dependence on food as a source of pleasure. Elevated norepinephrine levels enhance arousal and energy expenditure, thereby increasing calorie burn. Increased serotonin levels are known to induce satiety and diminish appetite, further aiding in weight reduction. The combined effect of these actions leads to a significant decrease in appetite and an increase in energy metabolism, promoting weight loss and an improved body composition. Tesofensine’s intricate mode of action provides a multi-faceted approach to managing weight and treating conditions with an underlying neurological component.

Tesofensine Specifications

Molecular Formula: C17H23Cl2NO

Molecular Weight:
328.3 g/mol

PubChem CID: 11370864

Buy Tesofensine from Direct Sarms Germany today! We supply premium grade research compounds at competitive prices and offer fast shipping worldwide.

Source: PubChem

Suggested Research Benefits of Tesofensine

Weight Loss Efficacy: – It shows significant potential in promoting weight loss by reducing appetite and boosting energy expenditure. It functions as an appetite suppressant, decreasing calorie intake and food cravings. Germany Studies show a notable increase in metabolic rate and energy levels, contributing to greater weight loss and improved body composition. Additionally, it helps individuals achieve their weight loss goals, supporting better weight management and a healthier lifestyle.
Improved Body Composition: Clinical studies show that it can help reduce body fat while maintaining lean muscle mass, promoting a healthier body composition that supports long-term weight management and overall health. It significantly boosts energy levels and metabolic rate, promoting sustained physical activity and better wellness. Additionally, Tesofensine helps maintain a balanced diet by controlling appetite and satiety, positively affecting blood sugar levels and insulin sensitivity.
Neurological Impact: Elevated neurotransmitter levels from TE may improve mood and cognitive function, benefiting patients with conditions like Parkinson’s and Alzheimer’s. The increase in dopamine is particularly helpful in activating reward pathways, alleviating depressive symptoms, and enhancing cognition. This dual effect on mood and weight makes it a promising candidate for Germany research in treating depression and improving central nervous system function.
Energy Metabolism Enhancement: By increasing norepinephrine levels, it can boost overall energy metabolism, potentially benefiting those with metabolic disorders. This increase in energy expenditure aids in better weight management and helps maintain a balanced basal metabolic rate. The improved metabolic rate leads to higher calorie burn, aiding in the treatment of obesity and related health conditions.
Appetite Regulation: Improved serotonin levels from TE contribute to better appetite control and enhanced satiety, crucial for managing obesity and related health issues. The compound’s effect on reducing food cravings and calorie intake supports healthier eating and lowers the risk of complications like diabetes and cardiovascular diseases. Additionally, balanced blood sugar levels are another benefit of it’s appetite regulation.
Potential Adjunct Therapy: It’s ability to modulate neurotransmitter activity suggests it could complement treatments for Parkinson’s and Alzheimer’s due to its positive effects on the central nervous system. Its antidepressant properties, from elevated dopamine, norepinephrine, and serotonin levels, make it a candidate for research in treating depressive disorders. This could benefit Germany individuals dealing with both obesity and mood disorders.
Pain management: Pain management with antidepressants is not new. Tricyclic antidepressants, one of the first mood disorder treatments, diminish nociception (pain perception), especially in fibromyalgia. Dopamine-boosting drugs increase the anti-nociceptive (anti-pain) effects of traditional antidepressants, which exclusively impact serotonin and norepinephrine. Hence, triple reuptake inhibitors like Tesofensine may help manage pain.

Buy Tesofensine Capsules

Buy Tesofensine Capsules Germany 0.5 mg per capsule and 99% purity online for research purposes. Enjoy the convenience of direct delivery, keeping your research running smoothly without interruptions.

What are the Potential Benefits of Tesofensine?

Weight Loss: Significant reductions in body weight through decreased appetite and increased energy expenditure.
Improved Body Composition: Reduction of fat mass while preserving lean muscle.
Enhanced Mood: Elevated dopamine levels contribute to improved mood and reduced dependence on food as a source of pleasure.
Increased Energy Expenditure: Higher norepinephrine levels enhance arousal and calorie burning.
Appetite Suppression: Increased serotonin levels induce satiety and diminish appetite.
Management of Neurological Conditions: Initial studies suggest potential benefits in treating neurological conditions such as Parkinson’s and Alzheimer’s diseases.

Frequently Asked Questions (FAQ’s) about Tesofensine

Is Tesofensine safe?

Clinical trials have demonstrated that TE is generally well-tolerated, but like all medications, it may have side effects. Common side effects include dry mouth, insomnia, and increased heart rate. It is crucial to follow Germany medical guidance and undergo regular monitoring while using Tesofensine.

Is Tesofensine legal?

The legality of Tesofensine varies by country and its pharmaceutical regulations. In some places, it may be approved for specific medical use, while in others, it remains under investigation.

The FDA in the U.S. has not approved Tesofensine for public use, and its legal status is still under review. Similarly, the Therapeutic Goods Administration (TGA) in Australia and the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK have not given approval for its use outside clinical settings.

Consult Germany local regulatory authorities to understand its legal status in your area. It’s also important to buy Tesofensine from reputable sources and follow local legal guidelines to ensure safety and compliance.

Can Tesofensine cause anxiety?

While Tesofensine shows promise for weight loss, researchers must be aware of possible side effects like anxiety. Some subjects may experience increased anxiety due to the drug’s impact on neurotransmitters like dopamine, noradrenaline, and serotonin, which regulate mood.

This anxiety can manifest as nervousness, restlessness, or even panic attacks. It’s crucial for researchers to monitor their subjects mental health and report any new or worsening symptoms to medical professionals. Proactive management with professional guidance can help mitigate risks and ensure safer treatment.

Does Tesofensine work?

Tesofensine has shown considerable promise in Germany clinical trials for its effectiveness in aiding weight loss. Studies indicate that Tesofensine can significantly reduce body weight in overweight and obese individuals when used alongside a balanced diet and regular exercise.

By inhibiting the reuptake of dopamine, noradrenaline, and serotonin, it facilitates sustained appetite suppression and increased energy expenditure. While individual results can vary, the evidence suggests that many trial subjects experience noticeable weight loss.

[1] M.H.Larsen, H.Rosenbrock, F.Sams-Dodd, and J.D.Mikkelsen “Expression of brain derived neurotrophic factor, activity-regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine”. European Journal of Pharmacology, 2007 Jan 26;555(2-3):115-21.

[2] A.Astrup, D.H.Meier, B.O.Mikkelsen, et al “Weight loss produced by tesofensine in patients with Parkinson’s or Alzheimer’s disease”. Obesity, Silver Spring Md, vol. 16, no. 6, pp. 1363–1369, Jun. 2008.

[3] A.Astrup, S.Madsbad, L.Breum et al “Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial”. The Lancet, 2008 Nov 29;372(9653):1906-1913.

[4] J.A.Gilbert, C.Gasteyger, A.Raben, et al “The effect of tesofensine on appetite sensations”. Obesity, Silver Spring Md volume 20, no. 3, pp. 553–561, Mar. 2012.

[5] A.M.D.Axel, J.D.Mikkelsen, and H.H.Hansen “Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat”. Neuropsychopharmacology, 2010 Jun;35(7):1464-76.

[6] B.M.Yung Cheung, T.Tsang Cheung, N.R.Samaranayake “Safety of antiobesity drugs”. Therapeutic Advances in Drug Safety, 2013 Aug 4, (4):171-81.

[7] A.Sjödin, C.Gasteyger, A.Lh.Nielsenet et al “The effect of the triple monoamine reuptake inhibitor tesofensine on energy metabolism and appetite in overweight and moderately obese men”. International Journal of Obesity, volume 34, no. 11, pp. 1634–1643, Nov. 2010.

[8] L.Appel, M.Bergström, J.B.Lassen, and B.Långström “Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: Dopamine transporter occupancy as measured by PET”. European Neuropsychopharmacology, Volume 24, Issue 2, February 2014, Pages 251-261.

[9] AB.Saniona “Saniona’s tesofensine meets primary and secondary endpoints in Phase 3 obesity registration trial”. Press Releases from GlobeNewswire News Room, Dec. 17, 2018.

[10] D.M.Marks, C.U.Pae, and A.A.Patkar “Triple Reuptake Inhibitors: The Next Generation of Antidepressants”. Current Neuropharmacology, 2008 Dec; 6(4): 338–343.

[11] Ł.R.Drzyzga, A.Marcinowska, and E.Obuchowicz “Antiapoptotic and neurotrophic effects of antidepressants: a review of clinical and experimental studies”. Brain Research Bulletin, Volume 79, Issue 5, 30 June 2009, Pages 248-257.

[12] S.M.Korte, J.Prins, A.M.Krajnc et al “The many different faces of major depression: it is time for personalized medicine”. European Journal of Pharmacology, 2015 Apr 15:753:88-104.

ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.

DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Germany Direct Sarms website is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

Peptide

Sarms

Other